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Merck
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108975

Sigma-Aldrich

亮抑酶肽，半硫酸盐，来源于微生物

Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases

别名:

亮抑酶肽，半硫酸盐，来源于微生物, Ac-LLR-CHO, ½H₂SO₄

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About This Item

经验公式（希尔记法）:
C20H38N6O4 · 0.5H2SO4
CAS号:
103476-89-7
分子量:
475.59
MDL编号:
MFCD00037012
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

200

描述

Merck USA index - 14, 5456

方案

≥90% (HPLC)

表单

lyophilized solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 50 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O

InChI

1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1

InChI key

GDBQQVLCIARPGH-ULQDDVLXSA-O

一般描述

胰蛋白酶样蛋白酶和半胱氨酸蛋白酶的可逆抑制剂。也已知抑制活化诱导的程序性细胞死亡并恢复HIV+供体的缺陷免疫应答。常用于内蛋白酶Lys-C、激肽释放酶、木瓜蛋白酶、纤溶酶、凝血酶、组织蛋白酶B、胰蛋白酶的抑制。亮肽素不抑制胰凝乳蛋白酶、弹性蛋白酶、肾素或胃蛋白酶。对于大多数应用，建议的工作范围是10-100 µM。

生化/生理作用

主要靶标
胰蛋白酶和半胱氨酸样蛋白酶
产物不与ATP竞争。
可逆性：是
细胞渗透性：否

警告

毒性：标准处理（A）

序列

Ac-Leu-Leu-arginal，半硫酸盐

重悬

复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。水性储备溶液在4°C下可稳定保存长达1周，在-20°C下可稳定保存长达1个月。

其他说明

Montenez, J.P., et al. 1994.Toxicol.Lett.73, 201.
Sarin, A., et al. 1994.J. Immunol.153, 862.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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