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Merck
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Key Documents

07-1387

Sigma-Aldrich

抗氧化-CaM激酶II(Met281/282)抗体

serum, from rabbit

别名:

CAMKK beta protein, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, Calcium/calmodulin-dependent protein kinase kinase beta, calcium/calmodulin-dependent protein kinase beta, calcium/calmodulin-dependent protein kinase kinase 2 beta, calcium/calmodulin-

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

mouse, rat, human

技術

immunocytochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... CAMK2D(817)

一般說明

Ca2+/钙调蛋白依赖性激酶家族包括CaM激酶I至IV,磷酸化酶激酶和MLCK。在没有刺激的情况下,CaM激酶是无活性的。与Ca2+/钙调蛋白的结合诱导构象变化和激活。CaM激酶具有广泛的底物特异性,具有许多细胞功能。

特異性

基于与免疫原序列的100%同源性,预期在小鼠和大鼠中发生交叉反应。
当在Met281/282上氧化时,该抗体可识别CaM激酶II。

免疫原

包含并包括氧化的Met281/282的合成肽。
表位:氧化Met281/282

應用

一个独立的实验室验证了该抗体在用盐水,AngII或Iso处理的小鼠心脏切片中的免疫细胞化学中起作用(Erickson,J.R.,2008)。
经验证,该抗氧化CaM激酶II(Met281/282)抗体可用于WB,IC检测氧化CaM激酶II(Met281/282)。

品質

通过蛋白质印迹在未处理和经H2O2处理的小鼠心脏细胞裂解液中进行了评估。

蛋白质印迹分析: 该抗体的1:1,000稀释液用于检测小鼠心脏细胞裂解液中氧化的CaM激酶II。

標靶描述

60 kDa

聯結

替代:04-1079

儲存和穩定性

自收到之日起,在-20°C条件下可稳定保存1年。
处理建议:收到后,在取下瓶盖之前,将小瓶离心并轻轻混合溶液。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


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Oral infections, particularly periodontitis, are a well-established risk factor for cardiovascular diseases, although the molecular mechanisms involved remain elusive. The aims of the present study were to investigate the effects of lipopolysaccharide derived from Porphyromonas gingivalis (PG-LPS) on cardiac function
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BioMed research international, 2017, 4150158-4150158 (2017-05-26)
Background. This study was undertaken to determine relative contributions of phosphorylation and oxidation to the increased activity of calcium/calmodulin-stimulated protein kinase II (CaMKII) in juveniles with cardiac myocyte dysfunction due to increased pressure overload. Methods. Juvenile rats underwent abdominal aortic
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Airway epithelial cells play important roles in allergic asthma. Transient receptor potential melastatin-related 2 (TRPM2) and oxidized Ca2+/calmodulin-dependent protein kinase Ⅱ (ox-CaMKⅡ) participate in the airway inflammation. This study aimed to analyze the effects of TRPM2 on ox-CaMKⅡ in the
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