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Merck
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Key Documents

07-1387

Sigma-Aldrich

抗氧化-CaM激酶II(Met281/282)抗体

serum, from rabbit

别名:

CAMKK beta protein, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, Calcium/calmodulin-dependent protein kinase kinase beta, calcium/calmodulin-dependent protein kinase beta, calcium/calmodulin-dependent protein kinase kinase 2 beta, calcium/calmodulin-

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

mouse, rat, human

技術

immunocytochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... CAMK2D(817)

一般說明

Ca2+/钙调蛋白依赖性激酶家族包括CaM激酶I至IV,磷酸化酶激酶和MLCK。在没有刺激的情况下,CaM激酶是无活性的。与Ca2+/钙调蛋白的结合诱导构象变化和激活。CaM激酶具有广泛的底物特异性,具有许多细胞功能。

特異性

基于与免疫原序列的100%同源性,预期在小鼠和大鼠中发生交叉反应。
当在Met281/282上氧化时,该抗体可识别CaM激酶II。

免疫原

包含并包括氧化的Met281/282的合成肽。
表位:氧化Met281/282

應用

一个独立的实验室验证了该抗体在用盐水,AngII或Iso处理的小鼠心脏切片中的免疫细胞化学中起作用(Erickson,J.R.,2008)。
经验证,该抗氧化CaM激酶II(Met281/282)抗体可用于WB,IC检测氧化CaM激酶II(Met281/282)。

品質

通过蛋白质印迹在未处理和经H2O2处理的小鼠心脏细胞裂解液中进行了评估。

蛋白质印迹分析: 该抗体的1:1,000稀释液用于检测小鼠心脏细胞裂解液中氧化的CaM激酶II。

標靶描述

60 kDa

聯結

替代:04-1079

儲存和穩定性

自收到之日起,在-20°C条件下可稳定保存1年。
处理建议:收到后,在取下瓶盖之前,将小瓶离心并轻轻混合溶液。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


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