推荐产品
生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
rabbit, hamster, mouse, human, rat
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... JAK1(3716)
特异性
JAK1
免疫原
HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)
应用
Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Immunological Signaling
质量
routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus
目标描述
130 kDa
外形
Antiserum
whole rabbit antiserum containing 0.05% sodium azide
储存及稳定性
2 years at -20°C
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
C F Lai et al.
The Journal of biological chemistry, 274(12), 7793-7802 (1999-03-13)
Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP
Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
Gonzalez-Garcia, A., et al
The Journal of Biological Chemistry, 272, 10220-10226 (1997)
Lixin Rui et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7260-E7267 (2016-11-02)
Janus kinases (JAKs) classically signal by activating STAT transcription factors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41 (H3Y41-P). In diffuse large B-cell lymphomas (DLBCLs), JAK signaling is a feature of the activated B-cell
Svantje Sobotta et al.
Frontiers in physiology, 8, 775-775 (2017-10-25)
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
Molden, J., et al
The Journal of Biological Chemistry, 272, 19625-19631 (1997)
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