P-063

苯妥英标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 经验公式（希尔记法）: C₁₅H₁₂N₂O₂
• CAS号: 57-41-0
• 分子量: 252.27
• UNSPSC代码: 41116107
• NACRES: NA.24

属性

• 等级: certified reference material
• 质量水平: 300
• 表单: liquid
• 特点: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• 制造商/商品名称: Cerilliant^®
• 浓度: 1.0 mg/mL in methanol
• 技术: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 应用: clinical testing
• 包装形式: single component solution
• 储存温度: −20°C
• SMILES字符串: O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
• InChI key: CXOFVDLJLONNDW-UHFFFAOYSA-N
• 基因信息: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般描述

Phenytoin is an antiepileptic drug used in the prevention and treatment of seizures. This analytical reference standard is suitable as starting material for the preparation of calibrators and controls in phenytoin testing by GC/MS or LC-MS/MS. Phenytoin is sold under the trade name Dilantin^®.

应用

• Advanced Separation and Extraction of Anticonvulsants: Phenytoin solution is utilized in the fabrication of surface molecularly imprinted polymer membranes. This innovative method enhances the separation and extraction of phenytoin, phenobarbital, and lamotrigine, significantly improving the precision and efficiency of drug monitoring in clinical and research settings (Zhao et al., 2024).


• LC-MS/MS Quantification for Drug Delivery: A sensitive LC-MS/MS method has been developed for the quantification of phenytoin and its major metabolite. This method is applied to both intravenous and intranasal delivery systems, enhancing our understanding of the pharmacokinetics and effectiveness of phenytoin as an anticonvulsant medication (Prentice et al., 2022).


• Clinical Decision Support for Pharmacogenomics: Phenytoin is involved in the appraisal and development of evidence-based clinical decision support systems. This research integrates pharmacogenomic data to optimize perioperative drug use, providing tailored therapeutic strategies based on genetic profiles, particularly for managing epilepsy treatments (Borden et al., 2021).


• Electromembrane Extraction Technique: The development of an electromembrane extraction method followed by capillary electrophoresis for phenytoin determination in exhaled breath condensate. This technique offers a non-invasive approach for therapeutic drug monitoring, critical for ensuring effective seizure control in epilepsy patients (Seyfinejad et al., 2020).


• Drug Crystallization Inhibition: Research into the use of polymer nanogels as reservoirs for phenytoin has shown potential in inhibiting drug crystallization. This approach could revolutionize drug delivery systems by maintaining the stability and bioavailability of phenytoin, enhancing its therapeutic efficacy for treating neurological disorders (Li et al., 2019).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Dilantin is a registered trademark of Warner-Lambert Co.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS02,GHS06,GHS08
• 警示用语：: Danger
• 危险声明: H225,H301 + H311 + H331,H370
• 预防措施声明: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危险分类: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 靶器官: Eyes,Central nervous system
• 储存分类代码: 3 - Flammable liquids
• WGK: WGK 2
• 闪点(°F): 49.5 °F - closed cup
• 闪点(°C): 9.7 °C - closed cup