D4505

5,5-二苯基海因 钠盐

≥99%

• 别名: 5,5-联苯基乙内酰脲, 苯妥英
• 线性分子式: C₁₅H₁₁N₂O₂Na
• CAS号: 630-93-3
• 分子量: 274.25
• EC號碼: 211-148-2
• MDL號碼: MFCD00069674
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277707
• NACRES: NA.77

属性

• 化驗: ≥99%
• 形狀: powder
• 溶解度: aqueous base: soluble
• SMILES 字串: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• InChI 密鑰: FJPYVLNWWICYDW-UHFFFAOYSA-M
• 基因資訊: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

说明

一般說明

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

應用

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds
• in seizure behavior testing as an anticonvulsant in Drosophila
• in in vivo embryo toxicity test in mouse embryonic stem cells

生化／生理作用

减少癫痫大发作的发生率；可能通过 Na⁺、K⁺ 和 Ca²⁺ 通道的影响而稳定可兴奋膜。

特點和優勢

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安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H302,H317,H361
• 防範說明: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges