QBD10593

DBCO-dPEG ^®₁₂-MAL

• 别名: Polyethylene glycol
• 经验公式（希尔记法）: C₅₂H₇₄N₄O₁₇
• 分子量: 1027.16
• UNSPSC代码: 51171641
• NACRES: NA.22

属性

• 方案: >90%
• 表单: solid or viscous liquid
• 反应适用性: reagent type: cross-linking reagent; reaction type: click chemistry
• 聚合物结构设计: shape: linear; functionality: heterobifunctional
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NCCC(N2C3=C(C#CC4=C(C2)C=CC=C4)C=CC=C3)=O
• InChI: 1S/C52H74N4O17/c57-48(14-18-55-50(59)11-12-51(55)60)54-17-20-63-22-24-65-26-28-67-30-32-69-34-36-71-38-40-73-42-41-72-39-37-70-35-33-68-31-29-66-27-25-64-23-21-62-19-15-49(58)53-16-13-52(61)56-43-46-7-2-1-5-44(46)9-10-45-6-3-4-8-47(45)56/h1-8,11-12H,13-43
• InChI key: RSPJSRPEBGDVOY-UHFFFAOYSA-N

说明

一般描述

DBCO-dPEG^®₁₂-MAL is a versatile heterobifunctional cross-linking reagent used in strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. This approach is also known as copper-free click chemistry. The presence of maleimidopropyl (MAL) functional group in the reagent forms a thiol-ether linkage with sulfhydryl groups.

特点和优势

DBCO-dPEG^®₁₂-MAL can be used to conjugate two different proteins or an antibody with a payload by using copper-free "click" chemistry with the DBCO and reaction of the maleimide with a free thiol.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable