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Merck

900921

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚(丙交酯--乙交酯)

PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50

别名:

PEG-PLGA, mPEG-b-PLGA

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About This Item

线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
分類程式碼代碼:
51171641
NACRES:
NA.23

形狀

crystals

品質等級

饋電比

lactide:glycolide 50:50

分子量

PEG average Mn 2,000
PLGA Mn 3,000

雜質

≤5000 ppm (residual monomer by GC)

運輸包裝

dry ice

儲存溫度

−20°C

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應用

生物相容性嵌段共聚物可用于形成用于药物递送的纳米颗粒。具有用于癌症药物、抗炎药、抗生素或麻醉剂的靶向或受控释放的潜力。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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