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Merck

739944

Sigma-Aldrich

Resomer® RG 504,聚(D,L-丙交酯-co-乙交酯)

lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000

别名:

PLGA

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

amorphous

饋電比

lactide:glycolide 50:50

分子量

Mw 38,000-54,000

降解時間

<3 months

黏度

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

轉變溫度

Tg 46-50 °C

儲存溫度

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI 密鑰

LCSKNASZPVZHEG-UHFFFAOYSA-N

應用

Resomer® RG 504, 聚(ᴅ,ʟ-丙交酯-co-乙交酯)可用于制备 聚合物纳米颗粒, 其是 天然抗癌物质的有效载体。

聚(D, L-丙交酯-co-乙交酯)微球可用于制造凝血酶的止血给药设备。

特點和優勢

控释生物活性剂,缝线和生物可吸收的植入装置

法律資訊

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Hannu Paajanen et al.
International journal of surgery (London, England), 11(1), 81-84 (2012-12-19)
Chronic pain may be a major long-term problem related to mesh material and operative trauma in inguinal hernioplasty. Lichtenstein hernioplasty was performed under local anaesthesia in 312 patients by the same surgeon and technique between 2003 and 2005. The patients

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Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

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