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形狀
amorphous
饋電比
lactide:glycolide 85:15
分子量
Mw 50,000-75,000
降解時間
<6 months
黏度
0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)
轉變溫度
Tg 45-50 °C
溶解度
ethyl acetate, chloroform, acetone and THF: soluble
儲存溫度
2-8°C
SMILES 字串
OCC(O)=O.CC(O)C(O)=O
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一般說明
封端酯基聚（D,L-丙交酯-乙交酯）(PLGA) 的特征特性为 体内 生物降解性、可调谐药物释放特性和极高的包封能力。
應用
PLGA 聚合物用于生产生物可降解医用缝线和控制药物释放。PLGA 微球已被报道用于人生长激素的控制释放。PLGA/聚己内酯/β 组成的共混聚合物薄膜-磷酸三钙已用于引导骨再生。
特點和優勢
控释生物活性剂、缝线和可生物吸收植入器件。
外觀
具有生物相容性且可生物降解的聚合物。
法律資訊
Lactel is a registered trademark of Evonik Corp
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers
Ayelen L Helling et al.
Tissue engineering. Part A, 25(3-4), 214-223 (2018-10-04)
In human skin the junction between the epidermis and dermis undulates. Epidermal stem cells pattern according to their position relative to those undulations. Here we describe a rig in which epidermal cells are cultured on a collagen-coated poly(d,l-lactide-co-glycolide) (PLGA) membrane.
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
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Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.
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