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Merck

389145

Sigma-Aldrich

(2-羟丙基)-β-环糊精

average Mw ~1,540

别名:

(2-Hydroxypropyl)-beta-cyclodextrin

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About This Item

EC 号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.22
价格与库存信息目前不能提供

表单

powder

质量水平

旋光性

[α]23/D +125°, c = 1 in H2O

分子量

average Mw ~1,540

标记范围

1.0 molar substitution dextrin

SMILES字符串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

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一般描述

2-羟丙基-β-环糊精是一种环状低聚糖,可用作药物赋形剂,以提高药物的稳定性和生物利用度。 [1] [2]

(2-羟丙基)-β-环糊精是一种羟烷基衍生物,主要用作制剂载体,以增加药物在水中的溶解,从而将药物成功递送至生物系统。通常用作α-、β-和γ-环糊精的替代物。[3]

应用

亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精(HBC)浓度线性增加,这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成,导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。
(2-羟丙基)-β-环糊精可用于:
  • 分别通过薄层色谱(TLC)和高效液相色谱(HPLC)测定药物制剂[4]和纳米颗粒制剂[5]中分析物的分析标准品。
  • 研究主客体与有机低分子量化合物的相互作用,然后使用反相HPLC技术对其进行定量。
  • 作为流动相添加剂,通过HPLC有效分离β-咔啉。[6]
  • 在环糊精修饰的胶束电动色谱(CD修饰的MEKC)中测定盐酸舍曲林及其合成相关产物。[7]
  • 作为手性选择剂,通过毛细管电泳分离泛酸。[8]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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2-Hydroxypropyl-$\beta$-cyclodextrin acts as a novel anticancer agent
Yokoo, et al.
PLoS ONE, 10, e0141946-e0141946 (2015)
M Agüeros et al.
Journal of pharmaceutical and biomedical analysis, 39(3-4), 495-502 (2005-06-11)
A rapid and simple HPLC method with evaporative scattering detection (ELSD) has been developed for the separation and quantitation of beta-cyclodextrin (beta-CD), 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) and poly(methyl vinyl ether-co-maleic anhydride) (Gantrez). Separation was carried out on a Zorbax Eclipse XDB-Phenyl narrow
2-Hydroxypropyl-$\beta$-cyclodextrin promotes transcription factor EB-mediated activation of autophagy
Song, et al.
The Journal of Biological Chemistry, 289, 10211-10222 (2014)
S E Lucangioli et al.
Journal of chromatography. A, 871(1-2), 207-215 (2000-03-29)
In this work development, optimization and validation of a cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) method is proposed to resolve separation of the sertraline hydrochloride and synthesis-related substances. Sertraline hydrochloride, the cis-(1S,4S) enantiomer form, is used as an antidepressant therapeutic
Direct chiral resolution of pantothenic acid using 2-hydroxypropyl-beta-cyclodextrin in capillary electrophoresis
Kodama S, et al.
Journal of Chromatography A, 811(1-2), 269-273 (1998)

Questions

  1. How to know a shelf life of 2-Hydroxypropyl)-β-cyclodextrin? Your product COA does not provide any information about a date of expiration. I'd appreciate your help. Thanks.

    1 answer
    1. This product does not contain an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

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