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Merck

359661

Sigma-Aldrich

H-Lys(Boc)-OH

≥95%, for peptide synthesis

别名:

Nε-Boc-L-赖氨酸

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About This Item

线性分子式:
(CH3)3COCONH(CH2)4CH(NH2)COOH
CAS号:
分子量:
246.30
Beilstein:
2417626
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.22

product name

H-Lys(Boc)-OH, ≥95%

化驗

≥95%

形狀

powder

光學活性

[α]20/D +18°, c = 1 in acetic acid

反應適用性

reaction type: solution phase peptide synthesis

mp

250 °C (dec.) (lit.)

應用

peptide synthesis

儲存溫度

2-8°C

SMILES 字串

CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O

InChI

1S/C11H22N2O4/c1-11(2,3)17-10(16)13-7-5-4-6-8(12)9(14)15/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)/t8-/m0/s1

InChI 密鑰

VVQIIIAZJXTLRE-QMMMGPOBSA-N

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一般說明

H-Lys(Boc)-OH又称为Nε-Boc-L-赖氨酸,常用于液相肽合成。

應用

H-Lys(Boc)-OH可制备五氟苯酯用于进一步合成β-肽。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Solution phase synthesis of beta-peptides using micro reactors
P Watts
Tetrahedron, 58, 5427-5439 (2002)
April Case et al.
Analytical biochemistry, 338(2), 237-244 (2005-03-05)
Tissue transglutaminase (TGase) is a Ca(2+)-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues. In addition to its transamidation activity, TGase can bind guanosine 5'-triphosphate (GTP) and does
Maria Moccia et al.
International journal of pharmaceutics, 397(1-2), 179-183 (2010-07-06)
A novel nucleic acid compaction device based on a positively-charged alpha,epsilon-poly-l-lysine was realized for the first time. The polycationic peptide was obtained by assembling Fmoc and Boc orthogonally protected l-lysine monomers by solid phase synthesis. The route to the novel
Xiang Gao et al.
Molecular pharmaceutics, 10(1), 187-198 (2012-12-19)
PEGylated lipopeptide surfactants carrying drug-interactive motifs specific for a peptide-nitroxide antioxidant, JP4-039, were designed and constructed to facilitate the solubilization of this drug candidate as micelles and emulsion nanoparticles. A simple screening process based on the ability that prevents the
C Toniolo et al.
International journal of peptide and protein research, 23(1), 47-54 (1984-01-01)
A solid-state and solution analysis of the homo-oligopeptides from epsilon-tert.-butyloxycarbonyl-L-lysine with p-oxymethylbenzylcholestan-3 beta-yl succinate as C-terminal group, using infrared absorption and circular dichroism, is described. The occurrence of intermolecular beta-structure is seen in the solid state and in solvents of

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