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Merck

156361

Sigma-Aldrich

海因

98%

别名:

2,4-咪唑啉二酮, 海因

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About This Item

经验公式(希尔记法):
C3H4N2O2
CAS号:
分子量:
100.08
Beilstein:
110598
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
价格与库存信息目前不能提供

品質等級

化驗

98%

形狀

powder

mp

218-220 °C (lit.)

SMILES 字串

O=C1CNC(=O)N1

InChI

1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)

InChI 密鑰

WJRBRSLFGCUECM-UHFFFAOYSA-N

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應用

本产品已被用作底物(在 40℃ 和 pH 9.0 下),以测定红小豆提取物中的 D -海因酶活性。
用于合成以下物质的反应物:
抗癌药物 N-苄基无赖氨酸视蛋白类似物[1]
D-谷氨酸基抑制剂[2]
抗糖尿病铬-2,4-噻唑烷二酮类[3]
具有脑渗透性的GSK-3β抑制剂[4]
作为 15-PGDH 抑制剂的噻唑烷二酮衍生物[5]
放射增敏剂[6]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Suguru Nishinami et al.
International journal of biological macromolecules, 114, 497-503 (2018-03-06)
Allantoin is widely used in pharmaceutical and cosmetic products, and is composed of a hydantoin ring and a ureido group. Recent reports showed that allantoin suppresses thermal aggregation of hen egg white lysozyme (LYZ). However, structural insight into the properties
Ying Wu et al.
Bioorganic & medicinal chemistry, 18(4), 1428-1433 (2010-02-04)
Prostaglandins have a short life in vivo because they are metabolized rapidly by oxidation to 15-ketoprostaglandins catalyzed by a cytosolic enzyme known as NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Previously, CT-8, a thiazolidinedione analogue, was found to be a potent inhibitor of
I Hauksson et al.
The British journal of dermatology, 174(2), 371-379 (2015-10-20)
Formaldehyde is a well-known contact sensitizer. Formaldehyde releasers are widely used preservatives in skincare products. It has been found that formaldehyde at concentrations allowed by the European Cosmetics Directive can cause allergic contact dermatitis. However, we still lack information on
Meltem Ceylan-Ünlüsoy et al.
Journal of enzyme inhibition and medicinal chemistry, 25(6), 784-789 (2010-08-07)
A series of chromonyl-2,4-thiazolidinediones/imidazolidinediones/2-thioxo-imidazolidine-4-ones (IIIa-i, IVa-i) was prepared by Knoevenagel reaction of 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4-one (IIa-c) with 2/3-formyl chromone (Ia-b) and then alkylation with methyl/ethyl iodide. The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds ıVb and ıVc
Narsimha Reddy Penthala et al.
Bioorganic & medicinal chemistry letters, 21(5), 1411-1413 (2011-02-08)
A series of novel substituted (Z)-5-((1-benzyl-1H-indol-3-yl)methylene)imidazolidin-2,4-diones (3a-f) and (Z)-5-((1-benzyl-1H-indol-3-yl)methylene)-2-iminothiazolidin-4-ones (3g-o) have been synthesized utilizing microwave irradiation. These analogs were evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3i exhibits potent growth inhibition against

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