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Merck

156361

Sigma-Aldrich

海因

98%

别名:

2,4-咪唑啉二酮, 海因

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About This Item

经验公式(希尔记法):
C3H4N2O2
CAS号:
分子量:
100.08
Beilstein:
110598
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
价格与库存信息目前不能提供

质量水平

方案

98%

表单

powder

mp

218-220 °C (lit.)

SMILES字符串

O=C1CNC(=O)N1

InChI

1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)

InChI key

WJRBRSLFGCUECM-UHFFFAOYSA-N

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应用

本产品已被用作底物(在 40℃ 和 pH 9.0 下),以测定红小豆提取物中的 D -海因酶活性。
用于合成以下物质的反应物:
抗癌药物 N-苄基无赖氨酸视蛋白类似物[1]
D-谷氨酸基抑制剂[2]
抗糖尿病铬-2,4-噻唑烷二酮类[3]
具有脑渗透性的GSK-3β抑制剂[4]
作为 15-PGDH 抑制剂的噻唑烷二酮衍生物[5]
放射增敏剂[6]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

June Izquierdo et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 25(53), 12431-12438 (2019-07-19)
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid
Effect of treatment with compressed CO2 and propane on D-hydantoinase activity
Andrade JM, et al.
Journal of Supercritical Fluids, 46(2), 342-350 (2008)
Y Thirupathi Reddy et al.
Bioorganic & medicinal chemistry letters, 20(2), 600-602 (2009-12-17)
A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three
Suguru Nishinami et al.
International journal of biological macromolecules, 114, 497-503 (2018-03-06)
Allantoin is widely used in pharmaceutical and cosmetic products, and is composed of a hydantoin ring and a ureido group. Recent reports showed that allantoin suppresses thermal aggregation of hen egg white lysozyme (LYZ). However, structural insight into the properties
Mohammad A Khanfar et al.
Journal of medicinal chemistry, 53(24), 8534-8545 (2010-11-19)
Dysregulation of glycogen synthase kinase (GSK-3β) is implicated in the pathophysiology of many diseases, including type-2 diabetes, stroke, Alzheimer's, and others. A multistage virtual screening strategy designed so as to overcome known caveats arising from the considerable flexibility of GSK-3β

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