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N-008

Supelco

(−)-nicotine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonyme(s) :

(−)-Nicotine solution

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About This Item

Formule empirique (notation de Hill):
C10H14N2
Numéro CAS:
54-11-5
Poids moléculaire :
162.23
Numéro Beilstein :
5733110
Numéro MDL:
MFCD00006369
Code UNSPSC :
41116107
ID de substance PubChem :
329818397
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

forensics and toxicology

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

CN1CCC[C@H]1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

Clé InChI

SNICXCGAKADSCV-JTQLQIEISA-N

Informations sur le gène

human ... CHRNA4(1137) , CHRNB2(1141)

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Catégories apparentées

Description générale

A Certified Spiking Solution® applicable for use in LC/MS or GC/MS applications such as nicotine testing, forensic analysis or clinical and diagnostic testing. Nicotine is a highly additive tobacco alkaloid associated with numerous health risks such as heart health, mental health and cancer.

Application


  • Chiral nicotine for neuroreceptor research: S(−)-Nicotine solution is extensively used in neuroreceptor studies, particularly targeting cholinergic receptors. This enantiopure nicotine variant helps in understanding the binding affinity and activity differences between nicotine isomers, contributing to more targeted neuropharmacological interventions (Lu and Gao, 2024).

  • Pharmacological experiments in addiction research: The optically active form of S(−)-Nicotine is critical for addiction research, where it is used to investigate the pharmacodynamics and addictive properties of nicotine. Studies using this compound help in developing therapeutic strategies for smoking cessation and understanding the biochemical pathways involved in nicotine addiction (Yang et al., 2024).

  • Enantiomer specificity in biochemical studies: High purity S(−)-Nicotine is crucial for assays that require precise control over biochemical properties. Its application in cholinergic receptor assays helps to elucidate the specific interactions and effects of the S(−) enantiomer compared to its R(+) counterpart, thereby enhancing the accuracy of pharmacological models (Mancuso et al., 2024).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

A-097

(+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

A-100

Anabasine-d4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

C-016

(−)-Cotinine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-017

(±)-Cotinine-d3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-035

(±)-Cotinine-d3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-048

(±)-Nicotine-d4 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

N-071

(±)-Nornicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-072

(±)-Nornicotine-d4, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-075

(±)-N′-Nitrosonornicotine (NNN) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-076

4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-077

(S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes,Central nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jia Gao et al.
Cell death & disease, 12(6), 508-508 (2021-05-20)
There is limited and discordant evidence on the role of nicotine in diabetic vascular disease. Exacerbated endothelial cell dysregulation in smokers with diabetes is associated with the disrupted adipose function. Adipokines possess vascular protective, anti-inflammatory, and anti-diabetic properties. However, whether
Muhammed Ershad et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 16(4), 452-457 (2020-03-18)
Cigarettes and other tobacco products may be extinguished by submersion in liquids in beverage cans or bottles. Cases of nicotine poisoning in children have been reported following ingestion of such liquids. The aim of this study is to analyze the
Lindsay F Stead et al.
The Cochrane database of systematic reviews, 11, CD000146-CD000146 (2012-11-16)
The aim of nicotine replacement therapy (NRT) is to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. The aims of this
Jie Wu et al.
Biochemical pharmacology, 86(8), 1173-1180 (2013-08-13)
Tobacco use is a major public health problem. Nicotine acts on widely distributed nicotinic acetylcholine receptors (nAChRs) in the brain and excites dopamine (DA) neurons in the ventral tegmental area (VTA). The elicited increase of DA neuronal activity is thought
Marina R Picciotto et al.
Neuropharmacology, 76 Pt B, 545-553 (2013-05-02)
Tobacco smoking in humans is one of the most persistent and widespread addictions and is driven by nicotine in tobacco smoke. Over the last several decades, understanding of the molecular and cellular basis for nicotine addiction has increased tremendously as
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