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C-016

Supelco

(−)-Cotinine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C10H12N2O
Numéro CAS:
486-56-6
Poids moléculaire :
176.22
Numéro CE :
200-659-6
Numéro MDL:
MFCD00077696
Code UNSPSC :
41116107
ID de substance PubChem :
329774764
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

forensics and toxicology

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

CN1C(CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

Clé InChI

UIKROCXWUNQSPJ-VIFPVBQESA-N

Catégories apparentées

Description générale

An analytical reference standard of the major urinary metabolite of nicotine. Not only is cotinine a biomarker for users of nicotine products including cigarettes, cigars, and snuff, but it′s also an alkaloid found in tobacco. Suitable uses for this analytical reference standard include as a starting material in calibrators and controls for GC/MS and LC/MS applications in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers.

Application


  • Biomarker Analysis in Medical Research: Examination of prolidase as a potential indicator of inflammation associated with cigarette smoking, where (-)-cotinine is a key biomarker, enhances understanding of chronic inflammation and its biochemical pathways in smokers (Yıldırım & Kulaksızoglu, 2024).

  • Comparative Toxicology Studies: Research evaluating blood biomarkers of inflammation in users of heated tobacco products compares these markers, including (-)-cotinine, with non-smoking individuals, offering insights into the inflammatory effects of new tobacco product usage on health (Świątkowska et al., 2024).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

A-097

(+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

A-100

Anabasine-d4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

C-017

(±)-Cotinine-d3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-035

(±)-Cotinine-d3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-008

(−)-nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-048

(±)-Nicotine-d4 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

N-071

(±)-Nornicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-072

(±)-Nornicotine-d4, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-075

(±)-N′-Nitrosonornicotine (NNN) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-076

4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-077

(S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Ana Florescu et al.
Therapeutic drug monitoring, 29(4), 437-446 (2007-08-02)
Exposure to environmental tobacco smoke (ETS) is most often estimated using questionnaires, but they are unreliable. Biomarkers can provide valid information on ETS exposure, the preferred biomarker being cotinine. However, no reference range of hair cotinine exists to distinguish among
Satu Kalliola et al.
The Journal of allergy and clinical immunology, 131(3), 730-735 (2013-02-06)
Exposure to tobacco smoke is a well-known risk factor for childhood asthma and reduced lung function, but the effect on airway inflammation in preschool-aged children is unclear. To examine the effect of parental smoking on lung function and fractional concentration
Shaan Gellatly et al.
Journal of inflammation research, 13, 175-185 (2020-05-06)
Electronic cigarettes (e-cigs) are relatively new devices that allow the user to inhale a heated and aerosolized solution. At present, little is known about their health effects in the human lung, particularly in the small airways (<2 mm in diameter)
Esther García-Esquinas et al.
Pediatrics, 131(5), e1415-e1423 (2013-04-10)
Active smoking and secondhand smoke (SHS) are known risk factors for kidney disease in adults. We evaluated the association between exposure to active smoking or SHS and kidney function in US adolescents. This is a cross-sectional study in 7516 adolescents
Sharon Saydah et al.
Pediatrics, 131(3), e679-e686 (2013-02-20)
To determine the risk of mortality associated with cardiometabolic risk factors in a national sample of adolescents and young adults. Prospective study of participants in the third NHANES (1988-1994), aged 12 to 39 years at the time of the survey
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