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T7515

Sigma-Aldrich

Sodium taurolithocholate

Synonym(e):

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Taurolithocholic acid sodium salt

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About This Item

Lineare Formel:
C26H44NO5SNa
CAS-Nummer:
Molekulargewicht:
505.69
UNSPSC-Code:
12161900
PubChem Substanz-ID:
NACRES:
NA.25

Beschreibung

anionic

Qualitätsniveau

Assay

≥97.0% (TLC)

Mol-Gew.

505.69 g/mol

Anwendung(en)

detection

SMILES String

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na]

InChI

1S/C26H45NO5S.Na.H/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

InChIKey

CMXYYIRKQPXCIE-RLHFEMFKSA-N

Allgemeine Beschreibung

Sodium taurolithocholate is a bile salt with detergent qualities that give it the ability to solubilize insoluble lipids.

Anwendung

Sodium taurolithocholate has been used in a study to assess factors controlling the gastrointestinal adsorption of petroleum hydrocarbon residues. It has also been used in a study to investigate the decrease in activity of Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) in rats where cholestasis had been induced.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is inefficiently conjugated in human and rodent
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Which way to die: the regulation of acinar cell death in pancreatitis by mitochondria, calcium, and reactive oxygen species.
Anna S Gukovskaya et al.
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