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T6260

Sigma-Aldrich

Taurochenodeoxycholinsäure Natriumsalz

Synonym(e):

2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethansulfonsäure Natriumsalz, 3α,7α-Dihydroxy-5β-cholan-24-säure-N-(2-sulfoethyl)amid Natriumsalz, Natrium-Taurocheno-desoxycholat

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About This Item

Empirische Formel (Hill-System):
C26H44NNaO6S
CAS-Nummer:
6009-98-9
Molekulargewicht:
521.69
Beilstein:
3901205
MDL-Nummer:
MFCD00036745
UNSPSC-Code:
41141802
PubChem Substanz-ID:
24900362
NACRES:
NA.25
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Beschreibung

anionic

Qualitätsniveau

200

Assay

≥95.0% (TLC)

Form

powder

Mol-Gew.

521.69 g/mol

CMC

4

HLB

20.1

Funktionelle Gruppe

sulfonic acid

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

InChI

1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17+,18-,19-,20+,21+,22-,24?,25+,26-;/m1./s1

InChIKey

IYPNVUSIMGAJFC-ULWOGUKGSA-M

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Allgemeine Beschreibung

Ein ionisches Detergens, das für die Solubilisierung von Lipiden und Proteinen eingesetzt wird.
Natriumtaurochendesoxycholat ist eine Gallensäure, die als anionisches Detergens verwendet werden kann. [1]

Anwendung

Natriumtaurochendesoxycholat wurde in einer Studie zur Untersuchung, ob Pankreas-β-Zellen zur BA-abhängigen Regulierung von Glucose beitragen, eingesetzt. [2] Es wurde außerdem in einer Studie zur Untersuchung der kurzfristigen Rückkopplungsregulierung von Natriumtaurocholat-Cotransporter-Polypeptid (NTCP) durch Gallensalze in vivo eingesetzt. [3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000396232
0000376041
0000339363
0000339361
0000322171

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Die Dokumentenbibliothek aufrufen

M B Jiménez-Castro et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(12), 3257-3271 (2012-09-22)
Numerous steatotic livers are discarded for transplantation because of their poor tolerance to ischemia-reperfusion (I/R). We examined whether tauroursodeoxycholic acid (TUDCA), a known inhibitor of endoplasmic reticulum (ER) stress, protects steatotic and nonsteatotic liver grafts preserved during 6 h in
Noritaka Kawasaki et al.
Scientific reports, 2, 799-799 (2012-11-15)
Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation and adipose tissue dysfunction. In this study, we observed that endoplasmic reticulum
Colin N Young et al.
The Journal of clinical investigation, 122(11), 3960-3964 (2012-10-16)
Although endoplasmic reticulum (ER) stress is a pathologic mechanism in a variety of chronic diseases, it is unclear what role it plays in chronic hypertension (HTN). Dysregulation of brain mechanisms controlling arterial pressure is strongly implicated in HTN, particularly in
T M Zaved Waise et al.
Molecular metabolism, 44, 101132-101132 (2020-12-03)
The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X receptor (FXR)) in the USI and ileum of
B I Cohen et al.
Journal of lipid research, 18(2), 223-231 (1977-03-01)
Sterol metabolism studies using a combination of isotopic and chromatographic procedures were carried out in rats fed either a low-cholesterol stock diet or a stock diet containing 0.1% cholesterol. The primary bile acids, sodium taurochenodeoxycholate and sodium taurocholate, were added
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. what is the solubility of Sodium taurochenodeoxycholate in DMSO, Ethanol or PBS?

    1 answer

    1. The product's solubility is tested in water at 100 mg/mL. No solubility data is available for the solvents DMSO, Ethanol, or Phosphate Buffered Saline.

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