SML1193

SU1498

≥98% (HPLC)

• Synonym(e): (2E)-2-Cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide, (E)-N-(3-Phenylpropyl)-cyano-3,5-diisopropyl-4-hydroxycinnamamide, AG-1498, SU 1498, Tyrphostin SU 1498, Tyrphostin SU1498
• Empirische Formel (Hill-System): C₂₅H₃₀N₂O₂
• CAS-Nummer: 168835-82-3
• Molekulargewicht: 390.52
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: −20°C
• InChI: 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
• InChIKey: JANPYFTYAGTSIN-FYJGNVAPSA-N

Beschreibung

Biochem./physiol. Wirkung

SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC₅₀ value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC₅₀ values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable