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T3434

Sigma-Aldrich

Tyrphostin AG 490

solid

Synonym(e):

2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

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About This Item

Empirische Formel (Hill-System):
C17H14N2O3
CAS-Nummer:
133550-30-8
Molekulargewicht:
294.30
MDL-Nummer:
MFCD00236452
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278732
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow

Löslichkeit

DMSO: soluble 10 mg/ml, clear, yellow
ethanol: 5 mg/mL
H2O: insoluble

Lagertemp.

−20°C

SMILES String

Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2

InChI

1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+

InChIKey

TUCIOBMMDDOEMM-RIYZIHGNSA-N

Angaben zum Gen

human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)

Anwendung

Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6.

Biochem./physiol. Wirkung

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Photosensitive

Angaben zur Herstellung

Tyrphostin AG 490 is soluble in ethanol at 5 mg/ml and is insoluble in water. It is also soluble in DMSO at 10 mg/ml and yields a clear, yellow solution.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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FM-381 ≥98% (HPLC)

Sigma-Aldrich

SML1979

FM-381

JAK2 Inhibitor II The JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420132

JAK2 Inhibitor II

JAK-Inhibitor I JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

Millipore

420099

JAK-Inhibitor I

AS1517499 ≥98% (HPLC)

Sigma-Aldrich

SML1906

AS1517499

AZD1480 ≥98% (HPLC)

Sigma-Aldrich

SML1505

AZD1480

U0126 ethanolate ≥98% (HPLC), powder

Sigma-Aldrich

U120

U0126 ethanolate

Tyrphostin A9 solid

Sigma-Aldrich

T182

Tyrphostin A9

J Abe et al.
The Journal of biological chemistry, 274(30), 21003-21010 (1999-07-20)
Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several hormones, we examined the role of JAK2 in ROS signal events. H(2)O(2) stimulated JAK2 activity in
Mengqi Jiang et al.
Oxidative medicine and cellular longevity, 2021, 7385160-7385160 (2021-08-31)
Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship is still poorly understood. Leptin, one of the most relevant factors secreted by adipose tissues, plays an important role in the pathogenesis of OA. Our aim
Pei-Ju Sung et al.
Cancer research, 79(14), 3651-3661 (2019-05-16)
Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 is associated with inhibition of tumor growth and metastasis. Although netrin-1 upregulation was initially described in cancer cells, we report here that in
K W Eriksen et al.
Leukemia, 15(5), 787-793 (2001-05-23)
Interleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells. IL-2Ralpha expression is restricted to T cells which have recently encountered antigen, and in healthy individuals the majority (>95%) of peripheral T
Wai Hoe Lau et al.
Oncotarget, 8(20), 32884-32904 (2017-04-22)
Activation of TLR3 stimulates cancer cell apoptosis and triggers secretion of inflammatory cytokines. PolyI:C, a TLR3 agonist, activates immune cells and regresses metastatic lung cancer in vivo. Although polyI:C reportedly kills lung carcinomas, the mechanism remains elusive. Here, we demonstrated
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