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SML0370

Sigma-Aldrich

Kartogenin

≥98% (HPLC)

Synonym(e):

2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN

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About This Item

Empirische Formel (Hill-System):
C20H15NO3
CAS-Nummer:
4727-31-5
Molekulargewicht:
317.34
MDL-Nummer:
MFCD00560510
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825371
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

DMSO: >15 mg/mL

Lagertemp.

room temp

SMILES String

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O

InChI

1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)

InChIKey

SLUINPGXGFUMLL-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

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Alix Barbe et al.
International journal of molecular sciences, 20(17) (2019-08-31)
Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1
Yoshitaka Imamichi et al.
The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)
11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression
Jun Zhao et al.
EBioMedicine, 36, 526-538 (2018-10-09)
Disordered folliculogenesis is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear. Long non-coding RNA (lncRNA) expression in luteinized granulosa cells (hLGCs) derived from women with and without PCOS were analyzed using microarray and
Yoshitaka Imamichi et al.
Scientific reports, 7(1), 8374-8374 (2017-08-23)
Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed
Jianying Zhang et al.
Bone research, 2 (2014-11-25)
Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to
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