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N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

Synonym(e):

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

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About This Item

Empirische Formel (Hill-System):
C13H18N2O5S
CAS-Nummer:
123653-11-2
Molekulargewicht:
314.36
MDL-Nummer:
MFCD00882995
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897540
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Farbe

off-white

mp (Schmelzpunkt)

127-128 °C

Löslichkeit

DMSO: >5 mg/mL
H2O: insoluble

SMILES String

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChIKey

KTDZCOWXCWUPEO-UHFFFAOYSA-N

Angaben zum Gen

human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743)
mouse ... Ptgs2(19225)

Anwendung

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:
  • the cardiac rate in zebrafish embryos
  • apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
  • the lipopolysaccharide (LPS) induced anorexia in rats

Biochem./physiol. Wirkung

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.
Selective cyclooxygenase-2 (COX-2) inhibitor.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Jihye Jung et al.
Cells, 8(7) (2019-06-30)
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1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac.
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