C8249

Kardamonin

≥98% (HPLC)

• Synonym(e): Alpinetinchalkon
• Empirische Formel (Hill-System): C₁₆H₁₄O₄
• CAS-Nummer: 19309-14-9
• Molekulargewicht: 270.28
• MDL-Nummer: MFCD00238554
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329775163
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: light yellow to dark brown
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: room temp
• SMILES String: O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC
• InChI: 1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
• InChIKey: NYSZJNUIVUBQMM-BQYQJAHWSA-N

Beschreibung

Anwendung

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.

Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples.

Biochem./physiol. Wirkung

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species).

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable