SML0320

FR180204

≥98% (HPLC)

• Synonym(e): 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204
• Empirische Formel (Hill-System): C₁₈H₁₃N₇
• CAS-Nummer: 865362-74-9
• Molekulargewicht: 327.34
• MDL-Nummer: MFCD14585805
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825325
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: faintly yellow to dark yellow
• Löslichkeit: DMSO: ≥10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5
• InChI: 1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
• InChIKey: XVECMUKVOMUNLE-UHFFFAOYSA-N

Beschreibung

Anwendung

FR180204 has been used as ERK inhibitor:

• to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
• of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
• to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Biochem./physiol. Wirkung

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

It can be used to study the roles of ERK as well as for drug development.

Leistungsmerkmale und Vorteile

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable