SML0315

CORM-A1

≥95% (NMR)

• Synonym(e): Sodium boranocarbonate
• Empirische Formel (Hill-System): CH₃BNa₂O₂
• CAS-Nummer: 17363-08-5
• Molekulargewicht: 103.82
• MDL-Nummer: MFCD18839226
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825320
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (NMR)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: >15 mg/mL
• Lagertemp.: room temp
• SMILES String: [Na+].[Na+].[BH3-]C([O-])=O
• InChI: 1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
• InChIKey: SOFPSQNQOQPAAJ-UHFFFAOYSA-M

Beschreibung

Anwendung

CORM-A1 has been used:

• to deliver carbon monoxide (CO) and to test its cytoprotection in yeast and primary astrocytes culture during oxidative stress
• as CO donor in murine macrophages J774A.1 cells to test its effect on cellular β-endorphins elevation
• to test its effect on mitophagy activation in retinal ganglion cells

Biochem./physiol. Wirkung

CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase is an important gaseous signaling mediator in mammalian cells CORM-A1 has anti-oxidant and anti-inflammatory activity.

It mediates the release of CO in a pH and temperature-dependent manner, thus favoring mild vasorelaxation and hypotension. During oxidative stress, CORM-A1 is reported to provide cytoprotection in astrocyte primary cultures. This boron-containing CORM promotes autophagy.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable