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S8751

Sigma-Aldrich

Sulfaguanidin

Synonym(e):

4-Amino-N-(aminoiminomethyl)-benzolsulfonamid, 4-Amino-N-guanylbenzolsulfonamid

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About This Item

Empirische Formel (Hill-System):
C7H10N4O2S
CAS-Nummer:
57-67-0
Molekulargewicht:
214.24
Beilstein:
2695326
EG-Nummer:
200-345-9
MDL-Nummer:
MFCD00038136
UNSPSC-Code:
51283914
PubChem Substanz-ID:
24899810
NACRES:
NA.85

Biologische Quelle

synthetic (Organic)

Qualitätsniveau

200

Form

powder

Farbe

white to off-white

Löslichkeit

1 M HCl: soluble 50 mg/mL

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

DNA synthesis | interferes
enzyme | inhibits

SMILES String

NC(=N)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)

InChIKey

BRBKOPJOKNSWSG-UHFFFAOYSA-N

Angaben zum Gen

human ... F2(2147) , PRSS1(5644)

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Verwandte Kategorien

Allgemeine Beschreibung

Chemical structure: sulfonamide

Anwendung

Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.

Biochem./physiol. Wirkung

Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLCP5182
SLBQ1293V
SLBD5155V
098K0683
026K0679

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B W Clare et al.
Journal of enzyme inhibition, 16(1), 1-13 (2001-08-11)
A series of compounds has been prepared by reaction of dicyandiamide with alkyl/arylsulfonyl halides as well as arylsulfonylisocyanates to locate a lead for obtaining weakly basic thrombin inhibitors with sulfonyldicyandiamide moieties as the S1 anchoring group. The detected lead was
H Sasaki et al.
Journal of pharmacobio-dynamics, 13(3), 200-205 (1990-03-01)
The enhancing effect of pyrrolidone derivatives on the percutaneous penetration of sulfaguanidine, aminopyrine and sudan III was investigated using in vitro technique and excised rat skin. 1-Methyl (MP), 1-hexyl (HP) and 1-lauryl-2-pyrrolidone (LP) were used as penetration enhancers. Aminopyrine showed
B Beauvais et al.
Antimicrobial agents and chemotherapy, 38(10), 2440-2448 (1994-10-01)
We have developed a new micromethod to study the effect of drugs on microsporidia, using MRC5 fibroblasts infected by 10(5) spores of Encephalitozoon cuniculi. After 3 days of incubation with various concentrations of drugs, parasitic foci were counted in stained
Vimal K Balakrishnan et al.
Journal of chromatography. A, 1131(1-2), 1-10 (2006-08-02)
In recent years, pharmaceutical and personal care products (PPCPs) have been detected in diverse environments (including groundwater, river water, and municipal wastewater). In order to evaluate their environmental impact, PPCPs must first be accurately determined. In this study, we focused
Alan D Gift et al.
Journal of pharmaceutical sciences, 98(12), 4670-4683 (2009-05-21)
Active pharmaceutical ingredients (API) can undergo an anhydrate to hydrate transformation during wet granulation and this transformation may either result in mixed crystalline forms or an unwanted form in the final drug product. Previous studies have shown that it may
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