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P8477

Sigma-Aldrich

Picotamide

Synonym(e):

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

Empirische Formel (Hill-System):
C21H20N4O3
CAS-Nummer:
32828-81-2
Molekulargewicht:
376.41
EG-Nummer:
251-245-7
MDL-Nummer:
MFCD00866792
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24278656
NACRES:
NA.83

Assay

≥98%

Qualitätsniveau

100

Form

powder

Löslichkeit

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES String

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChIKey

KYWCWBXGRWWINE-UHFFFAOYSA-N

Angaben zum Gen

human ... TBXA2R(6915)

Biochem./physiol. Wirkung

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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P A Modesti et al.
European journal of pharmacology, 169(1), 85-93 (1989-10-04)
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide
G Bettinetti et al.
Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)
A Giustina et al.
Diabetes, 47(3), 423-430 (1998-03-31)
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who
M Y Abeywardena et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)
Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with
G D'Andrea et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 27 Suppl 2, S96-S99 (2006-05-12)
Migraine with aura (MwA) sufferers, at times, need specific treatments. This is the case when the auras are frequent, prolonged and cause anxiety and distress. Abnormal release of glutamate, which may trigger auras, and abnormal platelet behaviour, which constitutes a
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