O0877

Oxolinsäure

quinolone antibiotic

• Synonym(e): 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]chinolin-7-carbonsäure
• Empirische Formel (Hill-System): C₁₃H₁₁NO₅
• CAS-Nummer: 14698-29-4
• Molekulargewicht: 261.23
• Beilstein: 620635
• EG-Nummer: 238-750-8
• MDL-Nummer: MFCD00056775
• UNSPSC-Code: 51282935
• PubChem Substanz-ID: 24278604
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Löslichkeit: 0.5 M NaOH: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
• InChI: 1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
• InChIKey: KYGZCKSPAKDVKC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: quinolone

Anwendung

Oxolinic acid is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia coli and Salmonella enterica. Oxolinic acid is added to culture medium for the isolation of Gardnerella vaginalis.

Biochem./physiol. Wirkung

Oxolinic acid is a quinolone antibiotic. It is a DNA-gyrase (topoisomerase II) inhibitor used for studies on DNA winding and coiling and acts as a dopamine reuptake inhibitor for studies on dopaminergic neurotransmission processes.

Sonstige Hinweise

5g,25g

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves