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I1774

Sigma-Aldrich

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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About This Item

CAS-Nummer:
52229-90-0
MDL-Nummer:
MFCD01094135
UNSPSC-Code:
12352202
NACRES:
NA.61

Produktbezeichnung

Iturin A from Bacillus subtilis, ≥95% (HPLC)

Biologische Quelle

Bacillus subtilis

Qualitätsniveau

200

Assay

≥95% (HPLC)

Form

powder

Methode(n)

microbiological culture: suitable

Farbe

white to yellow

Löslichkeit

ethanol: soluble 9.80-10.20 mg/mL

Wirkungsspektrum von Antibiotika

fungi

Wirkungsweise

cell membrane | interferes

Lagertemp.

2-8°C

Anwendung

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).

Biochem./physiol. Wirkung

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.

Sonstige Hinweise

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000410402
0000383063
0000383064
0000377029
0000410402

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M A Klich et al.
Mycopathologia, 127(2), 123-127 (1994-08-01)
The removal of many synthetic fungicides from the market has created a demand for new, environmentally safe fungicides. Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has strong antifungal properties and low mammalian toxicity. To determine the efficacy of
Thimon, L., et al.
Cytobios, 79, 96-96 (1994)
R Maget-Dana et al.
Toxicology, 87(1-3), 151-174 (1994-02-28)
Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis. These amphiphilic compounds are characterized by a peptide ring of seven amino acid residues including an invariable D-Tyr2, with the constant chiral sequence
Feng-Chia Hsieh et al.
Current microbiology, 56(1), 1-5 (2007-11-21)
Lipopeptides represent a unique class of bioactive microbial secondary metabolites, and iturin A shows attractive antibiotic properties among them. This study compares three methods, such as yeast/fungal growth inhibition assay, quantitative high-performance liquid chromatography (HPLC) and polymerase chain reaction (PCR)
Scott W Pryor et al.
Journal of agricultural and food chemistry, 55(23), 9530-9536 (2007-10-24)
Partial least squares (PLS) regression modeling was used to relate the antifungal activity of Bacillus subtilis solid-state fermentation extracts to the individual high-performance liquid chromatography (HPLC) peaks from those extracts. A model was developed that predicted bioassay inhibition based on
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