D7802

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

• Synonym(e): 4′,7-Dihydroxy-isoflavon, 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-on, 7-Hydroxy-3-(4-hydroxyphenyl)-chromon, Isoaurostatin
• Empirische Formel (Hill-System): C₁₅H₁₀O₄
• CAS-Nummer: 486-66-8
• Molekulargewicht: 254.24
• Beilstein: 231523
• EG-Nummer: 207-635-4
• MDL-Nummer: MFCD00016954
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24278030
• NACRES: NA.77

Eigenschaften

• product name: Daidzein, ≥98%, synthetic
• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥98%
• Form: powder
• mp (Schmelzpunkt): >290 °C
• Löslichkeit: DMSO: 10 mg/mL
• Lagertemp.: −20°C
• SMILES String: Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChIKey: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
• Angaben zum Gen: human ... ESR1(2099) , ESR2(2100) , UGT1A4(54657) ; mouse ... Aldh1a2(19378) , Hexa(15211) , Maoa(17161) ; rat ... Aldh1a2(116676)

Beschreibung

Allgemeine Beschreibung

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Anwendung

Daidzein has been used:

• as a control to evaluate fertility in rats
• to study its effects on ovarian cancer
• to simulate in vitro antioxidant activity

Biochem./physiol. Wirkung

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. Arrests cell cycle at G₁ in Swiss 3T3 cells.

Verpackung

abgefüllt unter Argon

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves