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H3160

Sigma-Aldrich

Hydrocortison

meets USP testing specifications

Synonym(e):

11β,17α,21-Trihydroxypregn-4-en-3,20-dion, 17-Hydroxykortikosteron, 4-Pregnen-11β,17α,21-triol-3,20-dion, Cortisol, Kendall’s Compound F, Reichstein’s Substance M

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About This Item

Empirische Formel (Hill-System):
C21H30O5
CAS-Nummer:
50-23-7
Molekulargewicht:
362.46
Beilstein:
1354819
EG-Nummer:
200-020-1
MDL-Nummer:
MFCD00011654
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24895560
NACRES:
NA.21

Biologische Quelle

plant (wild yam)

Qualitätsniveau

300

Agentur

USP/NF
meets USP testing specifications

Assay

97.0-102.0% dry basis

Form

powder

Wirksamkeit

0.004-0.005 μg/mL

mp (Schmelzpunkt)

211-214 °C (lit.)

Löslichkeit

water: soluble 0.28 g/L at 25 °C

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

JYGXADMDTFJGBT-VWUMJDOOSA-N

Angaben zum Gen

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

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Verwandte Kategorien

Anwendung


  • Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).

  • Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).

Biochem./physiol. Wirkung

Primäres Glucocorticoid im Sekret der Nebennierenrinde. Hat ein dreimal so hohes entzündungshemmendes Potential wie Corticosteron bei einem deutlich geringeren Potential zur Na2+-Retention.

Physikalische Form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360Df,H373

Gefahreneinstufungen

Repr. 1A - STOT RE 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
Lorenz Goette et al.
Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
Marianne Oksnes et al.
The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
Rachel Yehuda et al.
The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD
Lex W Doyle et al.
Neonatology, 98(2), 111-117 (2010-02-13)
Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants.
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