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G0923

Sigma-Aldrich

Golgicide A

≥98% (HPLC)

Synonym(e):

6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, CID 25113626, GCA

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About This Item

Empirische Formel (Hill-System):
C17H14F2N2
CAS-Nummer:
1005036-73-6
Molekulargewicht:
284.30
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329799717
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

room temp

SMILES String

Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4

InChI

1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1

InChIKey

NJZHEQOUHLZCOX-FTLRAWMYSA-N

Anwendung

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Biochem./physiol. Wirkung

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Chia J, et al.
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Onya Opota et al.
Microbes and infection, 19(11), 546-552 (2017-08-15)
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity
A conserved role for the ESCRT membrane budding complex in LINE retrotransposition.
Horn AV, et al.
PLoS Genetics, 13(6), e1006837-e1006837 (2017)
Hélène Gingras et al.
Microbial genomics, 4(2) (2018-01-11)
In order to expedite the discovery of genes coding for either drug targets or antibiotic resistance, we have developed a functional genomic strategy termed Plas-Seq. This technique involves coupling a multicopy suppressor library to next-generation sequencing. We generated an Escherichia
Sravani Banerjee et al.
PLoS pathogens, 14(5), e1007086-e1007086 (2018-05-22)
RNA viruses induce specialized membranous structures for use in genome replication. These structures are often referred to as replication organelles (ROs). ROs exhibit distinct lipid composition relative to other cellular membranes. In many picornaviruses, phosphatidylinositol-4-phosphate (PI4P) is a marker of
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