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F7301
Fibroblast Growth Factor-18 human
>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder
Synonym(e):
FGF-18
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About This Item
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in E. coli
Assay
>95% (SDS-PAGE and HPLC)
Form
lyophilized powder
Wirksamkeit
≤0.5 ng/mL
Mol-Gew.
predicted mol wt 21.2 kDa
Verpackung
pkg of 25 μg
Lagerbedingungen
avoid repeated freeze/thaw cycles
Verunreinigungen
endotoxin, tested
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... FGF18(8817)
Allgemeine Beschreibung
FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.
Biochem./physiol. Wirkung
FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.
FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.
Hinweis zur Analyse
The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.
Signalwort
Warning
H-Sätze
P-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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The crystal structure of fibroblast growth factor 18 (FGF18).
Alan Brown et al.
Protein & cell, 5(5), 343-347 (2014-03-29)
Wei Wei et al.
The Journal of clinical investigation, 123(10), 4435-4448 (2013-09-11)
High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has
Yoshifumi Mori et al.
The Journal of biological chemistry, 289(14), 10192-10200 (2014-03-01)
To identify genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initially compared four types of chondrocytes: articular (AA) versus growth plate (AG) cartilage chondrocytes in adult rats, and superficial layer (IS) versus deep layer
Shuk Yee Ngan et al.
Current protocols, 2(1), e341-e341 (2022-01-14)
Human embryonic stem cells (ES) and induced pluripotent stem cells (iPSC) are powerful tools that have the potential to generate in vitro human lung epithelial cells. However, challenges in efficiency and reproducibility remain in utilizing the cells for therapy discovery
Amy P Wong et al.
Nature protocols, 10(3), 363-381 (2015-02-06)
Airway epithelial cells are of great interest for research on lung development, regeneration and disease modeling. This protocol describes how to generate cystic fibrosis (CF) transmembrane conductance regulator protein (CFTR)-expressing airway epithelial cells from human pluripotent stem cells (PSCs). The
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