F9786
Fibroblast Growth Factor-Basic Heparin Stabilized human
recombinant, expressed in E. coli, aqueous solution, suitable for cell culture
Synonym(e):
rhbFGF
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product name
Fibroblast Growth Factor-Basic Heparin Stabilized human, FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in E. coli
Sterilität
sterile-filtered
Form
aqueous solution
Wirksamkeit
0.03-3.0 ng/mL ED50/EC50
Qualität
endotoxin tested
Verpackung
pkg of 1 and 5 mL
Methode(n)
cell culture | mammalian: suitable
UniProt-Hinterlegungsnummer
Lagertemp.
2-8°C
Angaben zum Gen
human ... FGF2(2247)
Allgemeine Beschreibung
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.
Anwendung
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.
Biochem./physiol. Wirkung
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair. It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system. FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor. bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types. In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion. It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
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Preisangaben
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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Zuzana Koledova et al.
Frontiers in cell and developmental biology, 7, 331-331 (2020-01-11)
Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate cellular behavior. In
Andrea Flesken-Nikitin et al.
Journal of visualized experiments : JoVE, (115) (2016-09-30)
Orthotopic transplantation assays in mice are invaluable for studies of cell regeneration and neoplastic transformation. Common approaches for orthotopic transplantation of ovarian surface and tubal epithelia include intraperitoneal and intrabursal administration of cells. The respective limitations of these methods include
Thi H Nguyen et al.
Nature chemistry, 5(3), 221-227 (2013-02-21)
Basic fibroblast growth factor (bFGF) is a protein that plays a crucial role in diverse cellular functions, from wound healing to bone regeneration. However, a major obstacle to the widespread application of bFGF is its inherent instability during storage and
Olivier Cases et al.
The Journal of biological chemistry, 288(23), 16655-16670 (2013-04-18)
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H Fukumoto et al.
Neuroscience letters, 122(2), 221-224 (1991-01-28)
Recombinant human basic fibroblast growth factor (rhbFGF) was found to induce secretion of nerve growth factor (NGF) in cultured astrocytes from rat brain. The induction was concentration dependent; a maximum increase of 2-fold was observed at concentrations of 3-10 ng/ml
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