E1631

β-Estradiol 17-Valerat

≥98% (HPLC), powder

• Synonym(e): 1,3,5(10)-Estratrien-3,17β-diol 17-pentanoat
• Empirische Formel (Hill-System): C₂₃H₃₂O₃
• CAS-Nummer: 979-32-8
• Molekulargewicht: 356.50
• Beilstein: 2480357
• EG-Nummer: 213-559-2
• MDL-Nummer: MFCD00056541
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 24894423
• NACRES: NA.77

Eigenschaften

• product name: β-Estradiol 17-Valerat, ≥98%
• Biologische Quelle: synthetic
• Qualitätsniveau: 100
• Assay: ≥98%
• Form: powder
• Methode(n): ELISA: suitable
• Löslichkeit: acetone: 25 mg/mL, hazy, colorless
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C
• InChI: 1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3
• InChIKey: RSEPBGGWRJCQGY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

β-Estradiol 17-valerate is a synthetic estrogen.

Anwendung

β-Estradiol 17-valerate has been used:

• in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
• to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
• to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Biochem./physiol. Wirkung

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H351,H361fd,H362,H410
• P-Sätze: P201 - P202 - P260 - P263 - P273 - P308 + P313
• Gefahreneinstufungen: Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges