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D8946

Sigma-Aldrich

DMH1

≥98% (HPLC), powder, BMP inhibitor

Synonym(e):

4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

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About This Item

Empirische Formel (Hill-System):
C24H20N4O
CAS-Nummer:
1206711-16-1
Molekulargewicht:
380.44
MDL-Nummer:
MFCD18384963
UNSPSC-Code:
51111800
PubChem Substanz-ID:
329798883
NACRES:
NA.77

product name

DMH1, ≥98% (HPLC)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

light yellow to orange

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

2-8°C

SMILES String

CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChIKey

JMIFGARJSWXZSH-UHFFFAOYSA-N

Allgemeine Beschreibung

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.

Anwendung

DMH1 has been used for bone morphogenetic protein (BMP) inhibition. It has also been used to block vascular endothelial growth factor (VEGF) signaling.

Biochem./physiol. Wirkung

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta
Lanza AR, et al.
Developmental Biology, 435(1), 26-40 (2018)
Silvia Colucci et al.
Blood, 130(19), 2111-2120 (2017-09-03)
The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP
Richard H Row et al.
eLife, 7 (2018-06-08)
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs)
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
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