D7006

Dihydrofolsäure

≥90%

• Synonym(e): 7,8-Dihydropteroyl-L-glutaminsäure
• Empirische Formel (Hill-System): C₁₉H₂₁N₇O₆
• CAS-Nummer: 4033-27-6
• Molekulargewicht: 443.41
• Beilstein: 69017
• MDL-Nummer: MFCD00083619
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24894068
• NACRES: NA.79

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥90%
• Form: powder
• Farbe: light yellow to dark yellow-orange
• Lagertemp.: −20°C
• SMILES String: NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
• InChI: 1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
• InChIKey: OZRNSSUDZOLUSN-LBPRGKRZSA-N
• Angaben zum Gen: human ... DHFRP1(573971) ; mouse ... Dhfr(13361)

Beschreibung

Allgemeine Beschreibung

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Anwendung

Dihydrofolic acid has been used in diaphorase-coupled assay for dihydrofolate reductase (DHFR) activity. It has also been used as a component in assay buffer to determine dihydrofolate reductase (DHFR) activity.

Biochem./physiol. Wirkung

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Verpackung

Verschweisste Ampulle

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves