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T3125

Sigma-Aldrich

Tetrahydrofolsäure

≥65% (when packaged), powder

Synonym(e):

5,6,7,8-Tetrahydropteroyl-L-glutaminsäure

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About This Item

Empirische Formel (Hill-System):
C19H23N7O6
CAS-Nummer:
135-16-0
Molekulargewicht:
445.43
Beilstein:
9238187
EG-Nummer:
205-181-1
MDL-Nummer:
MFCD00135583
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24900106
NACRES:
NA.51

Biologische Quelle

synthetic

Qualitätsniveau

200

Form

powder

Konzentration

≥65% (when packaged)

Farbe

faintly yellow to light brown

Löslichkeit

0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow

Lagertemp.

−20°C

SMILES String

NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1

InChI

1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChIKey

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

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Anwendung

Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches.
Tetrahydrofolic acid may also be used as a standard to generate calibration curve to quantify the folate types produced by Streptococcus thermophilus in milk cultures using high-performance liquid chromatography (HPLC). It is also suitable for use in the enzymatic assay of formate-tetrahydrofolate ligase from M. extorquens (MeFtfL).

Biochem./physiol. Wirkung

Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids

Verpackung

Verschweisste Ampulle

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

803049

Folsäure-(Glutaminsäure-13C5)

Dihydrofolate Reductase human ≥80% (SDS-PAGE), recombinant, expressed in E. coli, ≥1 units/mg protein

Sigma-Aldrich

D6566

Dihydrofolate Reductase human

DHFR from mouse recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sigma-Aldrich

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Folsäure British Pharmacopoeia (BP) Reference Standard

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Folsäure

Folsäure BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sigma-Aldrich

F8758

Folsäure

Changhua Yu et al.
Journal of cancer research and clinical oncology, 138(2), 255-259 (2011-11-23)
The purpose of the current study is to evaluate the efficacy and complications of concurrent chemoradiotherapy (CCRT) for the treatment of gastric cancer patients after D1/D2 surgery. Sixty-eight untreated gastric cancer patients (T3/T4 and/or N+) were enrolled. After surgery, they
Tyler D Ames et al.
Chemistry & biology, 17(7), 681-685 (2010-07-28)
Comparative sequence analyses of bacterial genomes are revealing many structured RNA motifs that function as metabolite-binding riboswitches. We have identified an RNA motif frequently positioned in the 5' UTRs of folate transport and biosynthesis genes in Firmicute genomes. Biochemical experiments
Avinash C Srivastava et al.
Plant physiology, 155(3), 1237-1251 (2011-01-15)
A recessive Arabidopsis (Arabidopsis thaliana) mutant with short primary roots and root hairs was identified from a forward genetic screen. The disrupted gene in the mutant encoded the plastidial isoform of folylpolyglutamate synthetase (FPGS), previously designated as AtDFB, an enzyme
Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells
Gao W, et al.
Journal for Immunotherapy of Cancer, 7(1), 231-231 (2019)
Aurora Meucci et al.
Food microbiology, 69, 116-122 (2017-09-25)
The ability of folate-producer strains of Streptococcus thermophilus to accumulate folates and the expression of two target genes (folK and folP), involved in the folate biosynthesis, were studied during milk fermentation. An over-expression of folK took place only in the
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