C8124

CH-223191

≥98% (HPLC), powder, AhR antagonist

• Synonym(e): 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide, 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide
• Empirische Formel (Hill-System): C₁₉H₁₉N₅O
• CAS-Nummer: 301326-22-7
• Molekulargewicht: 333.39
• MDL-Nummer: MFCD00377884
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329775161
• NACRES: NA.77

Eigenschaften

• product name: CH-223191,
• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Farbe: orange-brown
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C
• InChI: 1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+
• InChIKey: LKTNEXPODAWWFM-GHVJWSGMSA-N

Beschreibung

Anwendung

CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells, TH17-IL-10+ cells and organoids.

Biochem./physiol. Wirkung

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It inhibited TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibited TCDD-induced luciferase activity with an IC50 of 30nM. Unlike some other AhR antagonists which display agonist activity at high concentrations, CH-223191 did not stimulate AhR-dependent transcription even at 100 micromolar. It is also specific for AhR, displaying no affinity for the estrogen receptor, as some other antagonists do.

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable