C4881

Chlortetracyclin -hydrochlorid

≥91.0% dry basis (HPLC)

• Synonym(e): 7-Chlor-tetracyclin -hydrochlorid
• Empirische Formel (Hill-System): C₂₂H₂₃ClN₂O₈ · HCl
• CAS-Nummer: 64-72-2
• Molekulargewicht: 515.34
• Beilstein: 3858364
• EG-Nummer: 200-591-7
• MDL-Nummer: MFCD00082440
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 24892735
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥91.0% dry basis (HPLC)
• Form: powder
• pKa (25 °C): 3.3; 7.4; 9.3
• mp (Schmelzpunkt): 210-215 °C (dec.) (lit.)
• Löslichkeit: 1 M NaOH: 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• Lagertemp.: −20°C
• SMILES String: Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
• InChI: 1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
• InChIKey: CBHYYLPALVVVEY-LYNLVHCPSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: tetracycline

Anwendung

Cell-permeable fluorescent probe for Ca²⁺ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Biochem./physiol. Wirkung

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacterial than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

Sonstige Hinweise

If stored frozen, chlortetracycline hydrochloride is expected to remain stable at least four years.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H315,H317,H319,H335,H361fd
• P-Sätze: P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves