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36799

Sigma-Aldrich

7-(Diethylamino)cumarin-3-carbonsäure

BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

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About This Item

Empirische Formel (Hill-System):
C14H15NO4
CAS-Nummer:
50995-74-9
Molekulargewicht:
261.27
Beilstein:
6145963
MDL-Nummer:
MFCD00068721
UNSPSC-Code:
12352106
PubChem Substanz-ID:
57649663
NACRES:
NA.32

Produktlinie

BioReagent

Qualitätsniveau

200

Assay

≥98.0% (HPCE)

mp (Schmelzpunkt)

222-224 °C (dec.) (lit.)

Löslichkeit

DMF: soluble
DMSO: soluble

Fluoreszenz

λex 409 nm; λem 473 nm in 0.1 M Tris pH 9.0

Eignung

suitable for fluorescence

SMILES String

CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1

InChI

1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)

InChIKey

WHCPTFFIERCDSB-UHFFFAOYSA-N

Anwendung

7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sonstige Hinweise

Fluoreszenzlabel für Aminmodifikation und Konjugation mit Proteinen.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Aninda Chatterjee et al.
Photochemistry and photobiology, 89(2), 280-293 (2012-09-26)
The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state absorption, emission and time-resolved fluorescence spectroscopy. We have observed that with gradual increase in concentration
Keisuke Ikeda et al.
Biochemical and biophysical research communications, 370(3), 525-529 (2008-04-09)
Amyloid beta-protein (Abeta) has been reported to interact with a variety of lipid species, although the thermodynamic driving force remains unclear. We investigated the binding of Abetas labeled with the dye diethylaminocoumarin (DAC-Abetas) to lipid bilayers under various conditions. DAC-Abeta-(1-40)
Keisuke Ikeda et al.
FEBS letters, 580(28-29), 6587-6595 (2006-11-28)
The formation of fibrils by amyloid beta-protein (Abeta) is considered as a key step in the pathology of Alzheimer's disease (AD). Inhibiting the aggregation of Abeta is a promising approach for AD therapy. In this study, we used biocompatible nanogels
Tiffany P Gustafson et al.
Chemical communications (Cambridge, England), 49(7), 680-682 (2012-12-12)
Nanothermometers composed from a gold nanorod core, temperature sensitive linker and fluorescent dye are reported. The nanothermometers have low fluorescence due to a self-quenching mechanism at temperatures below 50 °C and become highly fluorescence above 70 °C.
Atsuko Kakio et al.
Biochemistry, 41(23), 7385-7390 (2002-06-05)
GM1 ganglioside-bound amyloid beta-protein (GM1-Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) plaques, has been suggested to accelerate amyloid fibril formation by acting as a seed. We have previously found using dye-labeled Abeta that Abeta recognizes
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