11126

Kaliumantimonyltartrat Trihydrat

puriss., meets analytical specification of USP, 99.0-103.0%, powder

• Synonym(e): Antimonkaliumtartrat, Brechweinstein (Kali)
• Empirische Formel (Hill-System): C₈H₄K₂O₁₂Sb₂ · 3H₂O
• CAS-Nummer: 28300-74-5
• Molekulargewicht: 667.87
• EG-Nummer: 234-293-3
• MDL-Nummer: MFCD00167056
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57646885
• NACRES: NA.21

Eigenschaften

• Qualität: puriss.; meets analytical specification of USP
• Qualitätsniveau: 200
• Assay: 99.0-103.0%
• Form: powder
• Verunreinigungen: ≤0.02 mmol/g free acid; ≤0.02 mmol/g free alkali
• Verlust: ≤2.7% loss on drying, 105 °C
• mp (Schmelzpunkt): ≥300 °C (lit.)
• Kationenspuren: As: ≤150 mg/kg; Pb: ≤20 mg/kg
• SMILES String: O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O
• InChI: 1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
• InChIKey: WBTCZEPSIIFINA-UHFFFAOYSA-J

Beschreibung

Allgemeine Beschreibung

Potassium antimonyl tartrate trihydrate is a trivalent antimonial compound. It has been reported to be more toxic than pentavalent antimony (Pentostam) against Leishmania species. Its crystal structure has been investigated by the three-dimensional X-ray and white radiation neutron diffraction techniques. It crystallizes in space group C222₁. Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Anwendung

Potassium antimonyl tartrate trihydrate was employed as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum†
It may also be used as a standard solution to determine the metalloid concentration such as Sb(III) and Sb(V) in surface soil, using high performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301,H315,H317,H332,H411
• P-Sätze: P261 - P273 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312
• Gefahreneinstufungen: Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves