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Key Documents

MAB342A4

Sigma-Aldrich

Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate

clone mGalC, from mouse, ALEXA FLUOR™ 488

Synonym(e):

Galactoceramide, Galactocerebroside, Galactosylceramide, GalC

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

ALEXA FLUOR™ 488

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

mGalC, monoclonal

Speziesreaktivität

rabbit, rat

Speziesreaktivität (Voraussage durch Homologie)

human, bovine (immunogen homology), chicken, mouse

Methode(n)

immunocytochemistry: suitable

Isotyp

IgG3

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GALC(2581)

Allgemeine Beschreibung

Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage.

Spezifität

This antibody recognizes Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold to a lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells.

Anwendung

Detect Galactocerebroside using this Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate validated for use in ICC.

Qualität

Evaluated by Immunocytochemistry in rat oligodendrocyte cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Galactocerebroside in rat oligodendrocyte cells. Performed without Triton.

Physikalische Form

Purified mouse monoclonal IgG3 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Hinweis zur Analyse

Control
Rat oligodendrocyte cells

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Shun Yamamuro et al.
International journal of oncology, 47(5), 1647-1654 (2015-09-24)
Glioma stem-like cells (GSCs) are undifferentiated cells that are considered to be an origin of glioblastomas. Furthermore, they may contribute to treatment resistance and recurrence in glioblastomas. GSCs differentiate into differentiated glioma cells (non-glioma stem-like cells: non‑GSCs), and interconversion might
Hal X Nguyen et al.
The Journal of comparative neurology, 522(12), 2767-2783 (2014-04-10)
Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) can differentiate into many cell types and are important for regenerative medicine; however, further work is needed to reliably differentiate hESC and hiPSC into neural-restricted multipotent derivatives or specialized
Juan F Reyes et al.
Glia, 62(3), 387-398 (2014-01-03)
The origin of α-synuclein (α-syn)-positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy (MSA) is enigmatic, given the fact that oligodendrocytes do not express α-syn mRNA. Recently, neuron-to-neuron transfer of α-syn was suggested to contribute to the pathogenesis

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