907340

H-L-Photo-Phe-OH

≥98%

• Synonym(e): (S)-2-Amino-3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid, 4-(Trifluoromethyldiazirin)-L-phenylalanine, Diazirine amino acid, H-Tdf-OH, Photo-Phe, Photo-crosslinking amino acid, Photoprobe building block
• Empirische Formel (Hill-System): C₁₁H₁₀F₃N₃O₂
• CAS-Nummer: 92367-16-3
• Molekulargewicht: 273.21
• MDL-Nummer: MFCD30187606
• UNSPSC-Code: 12352101

Eigenschaften

• Assay: ≥98%
• Form: powder
• Eignung der Reaktion: reaction type: solution phase peptide synthesis
• Verfügbarkeit: available only in USA
• Anwendung(en): peptide synthesis
• Lagertemp.: −20°C
• SMILES String: FC(F)(F)C2(N=N2)c1ccc(cc1)CC(N)C(=O)O
• InChI: 1S/C11H10F3N3O2/c12-11(13,14)10(16-17-10)7-3-1-6(2-4-7)5-8(15)9(18)19/h1-4,8H,5,15H2,(H,18,19)
• InChIKey: HRGXDARRSCSGOG-UHFFFAOYSA-N

Beschreibung

Anwendung

H-L-Photo-Phe-OH is a diazirine-containing phenylalanine amino acid and multifunctional
photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907294.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Sonstige Hinweise

Genetic Incorporation of a Photo-Crosslinkable Amino Acid Reveals Novel Protein Complexes with GRB2 in Mammalian Cells

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

A genetically encoded diazirine photo-crosslinker in Escherichia coli

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Danger
• H-Sätze: H242
• P-Sätze: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Gefahreneinstufungen: Self-react. C
• Lagerklassenschlüssel: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable