764736

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average M_n 2,000, PDLLA average M_n 2,000

• Synonym(e): PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA
• UNSPSC-Code: 12162002
• NACRES: NA.23

Eigenschaften

• Form: pellets
• Qualitätsniveau: 100
• Mol-Gew.: PDLLA average M_n 2,000; PEG average M_n 2,000; average M_n 4,000 (total)
• Zeitrahmen für den Abbau: 2-5 weeks
• Übergangstemp.: T_m 29-33 °C
• PDI: <1.1 (typical PEG); <1.2; <1.3 (overall)
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

Anwendung

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

Leistungsmerkmale und Vorteile

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): >230.0 °F
• Flammpunkt (°C): > 110 °C