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L-Tryptophanol
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About This Item
Empirische Formel (Hill-System):
C11H14N2O
CAS-Nummer:
Molekulargewicht:
190.24
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.22
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Qualitätsniveau
Assay
97%
Optische Aktivität
[α]20/D −20.5°, c = 1 in methanol
Eignung der Reaktion
reaction type: solution phase peptide synthesis
mp (Schmelzpunkt)
73-77 °C (lit.)
Anwendung(en)
peptide synthesis
SMILES String
N[C@H](CO)Cc1c[nH]c2ccccc12
InChI
1S/C11H14N2O/c12-9(7-14)5-8-6-13-11-4-2-1-3-10(8)11/h1-4,6,9,13-14H,5,7,12H2/t9-/m0/s1
InChIKey
UDQCRUSSQAXPJY-VIFPVBQESA-N
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Mercedes Amat et al.
The Journal of organic chemistry, 74(3), 1205-1211 (2008-12-17)
The enantioselective construction of the 3-ethylindolo[2,3-a]quinolizidine moiety present in numerous indole alkaloids is reported, the key steps being a stereoselective cyclocondensation of (S)-tryptophanol with an appropriate racemic delta-oxoester and a regio- and stereoselective cyclization of the resulting oxazolopiperidones on the
Ashley A Reinke et al.
Chembiochem : a European journal of chemical biology, 11(13), 1889-1895 (2010-08-03)
In Alzheimer's disease (AD) and other neurodegenerative disorders, proteins accumulate into ordered aggregates, called amyloids. Recent evidence suggests that these structures include both large, insoluble fibrils and smaller, prefibrillar structures, such as dimers, oligomers, and protofibrils. Recently, focus has shifted
E L Paley et al.
Experimental cell research, 195(1), 66-78 (1991-07-01)
Bovine kidney cell lines resistant to tryptamine and tryptophanol (tryptophan analogs) were selected. The content of tryptophanyl-tRNA synthetase (WRS, EC 6.1.1.2) was assayed by measuring the binding of monospecific polyclonal antibodies to the 35S-labeled enzyme in detergent-soluble and -insoluble forms
Theodoros Eleftheriadis et al.
Biomolecules, 9(12) (2019-12-11)
Along with infections, ultrafiltration failure due to the toxicity of glucose-containing peritoneal dialysis (PD) solutions is the Achilles' heel of PD method. Triggered by the protective effect of general control nonderepressible-2 (GCN-2) kinase activation against high-glucose conditions in other cell
Theodoros Eleftheriadis et al.
International journal of molecular medicine, 42(1), 557-568 (2018-04-26)
It is generally hypothesized in the literature that indoleamine 2,3‑dioxygenase (IDO), by degrading L‑tryptophan along the kynurenine pathway, suppresses CD4+ T‑cell function by inducing apoptosis, inhibiting proliferation and promoting differentiation towards a regulatory phenotype. These effects are either accompanied or
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