270148

(R)-3-Hydroxy-2-methyl-propionsäure-methylester

99%

• Synonym(e): (−)-Methyl-D-β-hydroxyisobutyrat, Methyl-(R)-(−)-3-hydroxy-2-methylpropionat
• Lineare Formel: HOCH₂CH(CH₃)CO₂CH₃
• CAS-Nummer: 72657-23-9
• Molekulargewicht: 118.13
• Beilstein: 3587507
• MDL-Nummer: MFCD00063450
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 24856357
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 99%
• Form: liquid
• Optische Aktivität: [α]19/D −26°, c = 4 in methanol
• Optische Reinheit: ee: 99% (GLC)
• Brechungsindex: n20/D 1.425 (lit.)
• bp: 76-77 °C/12 mmHg (lit.)
• Dichte: 1.066 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: ester; hydroxyl
• SMILES String: COC(=O)[C@H](C)CO
• InChI: 1S/C5H10O3/c1-4(3-6)5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
• InChIKey: ATCCIZURPPEVIZ-SCSAIBSYSA-N

Beschreibung

Anwendung

The (R)- and (S)-isomers are bifunctional building blocks for the synthesis of a wide variety of optically active molecules.

Methyl (R)-(-)-3-hydroxy-2-methylpropionate may be used in the preparation of (S)-(4-benzyloxy-3-methylbut-1-ynyl)triethylsilane. It may also be used as a starting material in the total synthesis of (-)-discodermolide, (-)-stemoamide and (-)-stemospironine.

Sicherheitshinweise

• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 176.0 °F - closed cup
• Flammpunkt (°C): 80 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter