112208

4-Nitrobenzoylchlorid

98%

• Synonym(e): p-Nitrobenzoyl chloride
• Lineare Formel: O₂NC₆H₄COCl
• CAS-Nummer: 122-04-3
• Molekulargewicht: 185.56
• Beilstein: 473192
• EG-Nummer: 204-517-4
• MDL-Nummer: MFCD00007345
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24847076
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 98%
• Form: solid
• bp: 202-205 °C/105 mmHg (lit.)
• mp (Schmelzpunkt): 71-74 °C (lit.)
• Funktionelle Gruppe: acyl chloride; nitro
• SMILES String: [O-][N+](=O)c1ccc(cc1)C(Cl)=O
• InChI: 1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H
• InChIKey: SKDHHIUENRGTHK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

4-Nitrobenzoyl chloride reacts with triphenylphosphonium salt to synthesize benzofurans (potential positron emission tomography (PET) tracers) by the intramolecular Wittig reaction.It has been used for the derivatisation of Adiol (Androstenediol, an endogenous proliferation agent of prostate cancer).

Anwendung

<ul>
<li><strong>Automated Synthesis of [11C]PiB:</strong> 4-Nitrobenzoyl chloride is utilized in the automated synthesis of [11C]PiB, a radiopharmaceutical for PET imaging of amyloid, highlighting its role in enhancing neuroimaging techniques (Singh et al., 2024).</li>
</ul>

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H290,H314
• P-Sätze: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flammpunkt (°F): 215.6 °F - closed cup
• Flammpunkt (°C): 102 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges