1568040

Proguanil hydrochloride

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• 실험식(Hill 표기법): C₁₁H₁₆ClN₅·HCl
• CAS Number: 637-32-1
• Molecular Weight: 290.19
• MDL number: MFCD01732193
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329750967
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: proguanil
• 제조업체/상표: USP
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• SMILES string: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI key: SARMGXPVOFNNNG-UHFFFAOYSA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

생화학적/생리학적 작용

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable