Y0002055

Fingolimod hydrochloride

European Pharmacopoeia (EP) Reference Standard

• 동의어(들): FTY720, 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride
• 실험식(Hill 표기법): C₁₉H₃₃NO₂ · HCl
• CAS Number: 162359-56-0
• Molecular Weight: 343.93
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• 생물학적 소스: synthetic
• Grade: pharmaceutical primary standard
• Agency: EP
• API family: fingolimod
• 양식: powder
• 포장: pkg of 110 mg
• 제조업체/상표: EDQM
• 저장 조건: protect from light
• solubility: water: 100-1000 g/L
• 응용 분야: pharmaceutical
• 형식: neat
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC
• InChI: 1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
• InChI key: SWZTYAVBMYWFGS-UHFFFAOYSA-N

설명

일반 설명

Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.[1][2][3][3]

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

생화학적/생리학적 작용

FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.

FTY720, an immunomodulating drug, acts as a sphingosine 1-phosphate (S1P) receptor modulator.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H373
• 예방조치 성명서: P260 - P314 - P501
• Hazard Classifications: STOT RE 2
• 표적 기관: Immune system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable