Stock solutions of this material may be aliquoted and stored at -20°C or below for up to 1 month.
PZ0280
CP-456773 sodium salt
CP-456773 sodium salt
≥98% (HPLC), powder, IL-1β secretion inhibitor
동의어(들):
CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H23N2NaO5S
CAS Number:
Molecular Weight:
426.46
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77
제품 PZ0280은(는)귀하의 국가에서 현재 판매되지 않습니다. 고객지원팀으로 연락바랍니다.
추천 제품
제품명
CP-456773 sodium salt, ≥98% (HPLC)
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
H2O: 20 mg/mL, clear
저장 온도
room temp
SMILES string
CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
InChI
1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChI key
LFQQNXFKPNZRFT-UHFFFAOYSA-M
애플리케이션
CP-456773 sodium salt has been used :
- In in vivo experiments to study the neuroprotective action of ketogenic diet.[1]
- To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.[2]
- To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.[3]
생화학적/생리학적 작용
CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.[4]
CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.
Chen L, et al.
Cellular and Molecular Life Sciences, 75(11), 2045-2058 (2018)
Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.
Primiano M J, et al.
Journal of Immunology, 197(6), 2421-2433 (2016)
Cong-Fa Huang et al.
Journal of experimental & clinical cancer research : CR, 36(1), 116-116 (2017-09-04)
NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of the head and neck
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.
Guo M, et al.
Frontiers in Molecular Neuroscience, 11, 86-86 (2018)
Lei Chen et al.
Cellular and molecular life sciences : CMLS, 75(11), 2045-2058 (2017-12-01)
The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that
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